Role of K + channels and NOS on human eccrine sweat gland function

Role of circulating catecholamines in human eccrine sweat gland control.

1. Intra-arterially as well as intradermally administered adrenaline or noradrenaline produces a sweat response. 2. The intensity of the intradermal response is always considerably less than that due to acetylcholine and the threshold of effective concentration is considerably greater than for acetylcholine. The glands also fail to respond to repeated small doses of intradermal catecholamine an...

Eccrine sweat gland carcinoma.

The differential diagnosis among the most frequent skin tumors, base-cell carcinoma and squamous-cell carcinoma, and the rare types, the sweat gland carcinomas, is fundamental for the early diagnosis and prognosis of a patient. These are classified as eccrine and apocrine, and the eccrine is the most common type. The eccrine sweat glands are most abundant in the palms of the hands and the feet ...

Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.

Eccrine sweat glands are essential for sweating and thermoregulation in humans. Loss-of-function mutations in the Ca2+ release-activated Ca2+ (CRAC) channel genes ORAI1 and STIM1 abolish store-operated Ca2+ entry (SOCE), and patients with these CRAC channel mutations suffer from anhidrosis and hyperthermia at high ambient temperatures. Here we have shown that CRAC channel-deficient patients and...

Sodium Secretion and Reabsorption in the Human Eccrine Sweat Gland.

Transductal fluxes of Na, K, and water in the human eccrine sweat gland.

MANGOS, JOHN. Transductal fluxes of Na, K, and water in the human eccrine sweat gland. Am. J. Physiol. 224(5): 1235-1240. 1973.--The bidirectional fluxes of Na, the net influx of K, and the net fluxes of water were studied in the human sweat duct in vitro by free-flow microperfusion with sweat resembling the primary secretory fluid and by microanalysis of the fluid samples obtained. Full-thickn...